Pathophysiology of oedema in idiopathic nephrotic syndrome
نویسندگان
چکیده
منابع مشابه
Pathophysiology of oedema in idiopathic nephrotic syndrome.
The decrease in plasma protein and colloid osmotic pressure (COP) in the nephrotic syndrome is accompanied by a decrease in tissue-fluid protein and COP. The latter protects against a fall in blood volume. However, the range and speed of this protective mechanism are limited, and a decrease in blood volume can be expected if plasma COP is below approximately 10 mmHg, or (temporarily) if the pro...
متن کامل[New insights into the pathophysiology of oedema in nephrotic syndrome].
Oedema is a common clinical manifestation of nephrotic syndrome. However, the pathophysiological mechanism of sodium retention in nephrotic syndrome has been intensely debated for decades. Several clinical and experimental observations argue against the classic or "underfill" hypothesis of oedema formation in nephrotic syndrome. In many patients, oedema formation in nephrotic syndrome is due to...
متن کاملImmunopathogenesis of idiopathic nephrotic syndrome.
Idiopathic nephrotic syndrome is the most frequent glomerular disease in children. The mechanisms underlying its pathophysiology have been investigated by genetic, cellular and molecular approaches. While genetic analyses have provided new insights into disease pathogenesis through the discovery of several podocyte genes mutated in distinct forms of inherited nephrotic syndrome, the molecular b...
متن کاملAminaphtone in idiopathic cyclic oedema syndrome.
OBJECTIVES Idiopathic cyclic oedema syndrome is a group of clinical conditions that exhibit a vascular capillary hyperpermeability accompanied by oedema caused by the interstitial retention of fluid. The objective of the current study was to evaluate the efficacy of aminaphtone in the treatment of idiopathic cyclic oedema. METHODS A total of 15 female patients with clinical diagnosis of idiop...
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Of 231 children with nephrotic syndrome, 87% were steroid sensitive and 13% steroid resistant. Of patients with steroid sensitive nephrotic syndrome, 38.8% were non-relapsers, 34.8% frequent relapsers and 26.4% infrequent relapsers. Among those with steroid resistant nephrotic syndrome, 37.5% had focal segmental glomerulosclerosis with a high mortality rate of 44%
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2003
ISSN: 1460-2385
DOI: 10.1093/ndt/gfg1063